{"id":2488,"date":"2026-01-14T03:12:44","date_gmt":"2026-01-14T08:12:44","guid":{"rendered":"https:\/\/carvunislab.csb.pitt.edu\/?p=2488"},"modified":"2026-01-14T03:16:31","modified_gmt":"2026-01-14T08:16:31","slug":"new-paper-on-the-role-of-tandem-repeats-and-stop-codon-mutations-in-a-human-de-novo-orf","status":"publish","type":"post","link":"https:\/\/carvunislab.csb.pitt.edu\/?p=2488","title":{"rendered":"New paper on the role of tandem repeats and stop codon mutations in a human <i>de novo<\/i> ORF"},"content":{"rendered":"<p>A new paper is out in Genome Biology and Evolution by lab members Lin and Jiwon. This study reconstructs the evolution of orf143, a long <i>de novo<\/i> human ORF that arose in simians from a noncoding region via a start-codon\u2013creating mutation and was subsequently elongated through stop codon disruption and tandem repeat expansion. The overlap of orf143 with oncogenic binding sites in the lncRNA VPS9D1-AS1 suggests that translation of this <i>de novo<\/i> ORF may confer a tumor-suppressive selective advantage. This study illustrates how elongation of <i>de novo<\/i> ORFs may provide a selective advantage. Check out the paper<\/p>\n\n\n<p><\/p>\n\n\n<figure class=\"wp-block-post-featured-image\"><img loading=\"lazy\" decoding=\"async\" width=\"466\" height=\"174\" src=\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2026\/01\/pic1.png\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"\" style=\"object-fit:cover;\" srcset=\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2026\/01\/pic1.png 466w, https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2026\/01\/pic1-300x112.png 300w\" sizes=\"auto, (max-width: 466px) 100vw, 466px\" \/><\/figure>","protected":false},"excerpt":{"rendered":"A new paper is out in Genome Biology and Evolution by lab members Lin and Jiwon. This study reconstructs the evolution of orf143, \n<a class=\"moretag\" href=\"https:\/\/carvunislab.csb.pitt.edu\/?p=2488\"> [...]<\/a>","protected":false},"author":3,"featured_media":2481,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[],"class_list":["post-2488","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/carvunislab.csb.pitt.edu\/index.php?rest_route=\/wp\/v2\/posts\/2488","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/carvunislab.csb.pitt.edu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/carvunislab.csb.pitt.edu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/carvunislab.csb.pitt.edu\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/carvunislab.csb.pitt.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2488"}],"version-history":[{"count":4,"href":"https:\/\/carvunislab.csb.pitt.edu\/index.php?rest_route=\/wp\/v2\/posts\/2488\/revisions"}],"predecessor-version":[{"id":2493,"href":"https:\/\/carvunislab.csb.pitt.edu\/index.php?rest_route=\/wp\/v2\/posts\/2488\/revisions\/2493"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/carvunislab.csb.pitt.edu\/index.php?rest_route=\/wp\/v2\/media\/2481"}],"wp:attachment":[{"href":"https:\/\/carvunislab.csb.pitt.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2488"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/carvunislab.csb.pitt.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2488"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/carvunislab.csb.pitt.edu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2488"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}