![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2025\/03\/wacholder-2-e1741713634647-1024x758.png\")
<\/figure>\n\n\n\nNew paper on the role of tandem repeats and stop codon mutations in a human de novo<\/i> ORF<\/h2>\n\n\n\n
January 13, 2026<\/p>\n\n\n\n
A new paper is out in Genome Biology and Evolution by lab members Lin and Jiwon. This study reconstructs the evolution of orf143, a long de novo<\/i> human ORF that arose in simians from a noncoding region via a start-codon\u2013creating mutation and was subsequently elongated through stop codon disruption and tandem repeat expansion. The overlap of orf143 with oncogenic binding sites in the lncRNA VPS9D1-AS1 suggests that translation of this de novo ORF may confer a tumor-suppressive selective advantage. This study illustrates how elongation of de novo<\/i> ORFs may provide a selective advantage. Check out the paper here<\/a><\/p>\n\n\n\n <\/p>\n\n\n\n November 10, 2025<\/p>\n\n\n\n We held a series of gatherings to celebrate our last days together with all members in Pittsburgh. It has been an honor to meet here and to do science side by side. This November, we will be moving to ETH Z\u00fcrich in Switzerland to begin a new scientific adventure. We are truly grateful to everyone in Pittsburgh for welcoming us, supporting us, and making this chapter so meaningful. Thank you, Yinz!<\/p>\n\n\n\n April 29, 2025<\/p>\n\n\n\n The lab spent the day participating in a fun research pitch activity, having lunch at Kaya, and playing mini golf at Puttshack. Congrats to April, Katie, and Lin for winning the research pitch activity and to Carly for winning mini golf! Thank you Nozomu for planning the day!<\/p>\n\n\n\n February 23, 2025<\/p>\n\n\n\n A new preprint by lab members Aaron and Jiwon assesses mass spectrometry-based identifications of human proteins from proteomics and peptidomics datasets. Check out the preprint here<\/a><\/p>\n\n\n\n February 7, 2025<\/p>\n\n\n\n Members of the Carvunis lab attended the Keystone Symposia Microproteins conference held in Beverly, MA. Congratulations to Carly who won an award!<\/p>\n\n\n\n January 6, 2025<\/p>\n\n\n\n The Carvunis Lab celebrated King’s Day on January 6th with a delicious Galette Des Rois (king cake) made by Nelson. Traditionally, one slice of the cake contains a small figurine, and the person who receives that slice is crowned the king. Whoever is crowned the king will have luck and good fortune for the year. Normally, the youngest person in the family closes their eyes and decides who gets each slice of the cake. In our lab, since Emma is the newest lab member, she chose. This year the king is Lin!<\/p>\n\n\n\n October 31, 2024<\/p>\n\n\n\n The Carvunis lab hosted a Halloween social hour for the CSB department with karaoke, spooky-themed food and drinks, and a costume contest. Thanks to Jiwon and others for all their hard work in organizing and planning this event, and congratulations to Lin, who won the costume contest for his spotted lanternfly costume!<\/p>\n\n\n\n October 25, 2024<\/p>\n\n\n\n Members in the Carvunis lab wrote a commentary for a recent study that quantified the key parameters for a homodimer to evolve into an obligate heterodimer through neutral evolution and discuss its implications in biological innovations. Read more about it here<\/a> September 10, 2024<\/p>\n\n\n\n New collaborative preprint details a framework for annotating noncanonical open reading frames (nORFs) in humans. Read more about it here<\/a><\/p>\n\n\n\n <\/p>\n\n\n\n August 29, 2024<\/p>\n\n\n\n This new preprint from the lab investigates common features between 26 de novo<\/em> emerging proteins that have previously been associated with growth benefits in yeast. Many of these de novo<\/em> emerging proteins preferentially localize to the ER and use evolutionarily conserved cell sorting pathways to get there. Read more about the cellular processing and localization of de novo<\/em> emerging proteins here<\/a>! <\/p>\n\n\n August 23, 2024<\/p>\n\n\n\n CPCB student April Rich was awarded the “Outstanding Research” award and the “Best Research Poster” award at this years annual CPCB retreat. Congratulations April!<\/p>\n\n\n July 31, 2024<\/p>\n\n\n\n On July 26, we had a farewell party for Breanna, Will, Kaite, and John. We wish them success in their careers and thank them for joining us!<\/p>\n\n\n\n July 9, 2024<\/p>\n\n\n\n April and Omer’s paper on the coexpression network of yeast noncanonical ORFs has now been published in Genome Biology. Check out the paper here<\/a>.<\/p>\n\n\n\n July 3, 2024<\/p>\n\n\n\n On July 2nd, we had a fantastic cultural potluck at Shenley Park! The event was a colorful mix of delicious dishes from various cultures, creating a lively and welcoming vibe.<\/p>\n\n\n\n June 27, 2024<\/p>\n\n\n\n The Carvunis Lab hosted an online Gene Expression Analysis Workshop on June 20th and 21st. We were thrilled to welcome participants from all over the world! We sincerely appreciate the enthusiastic participation and engagement from everyone who attended. Your contributions made the event a success! All modules are still available online for those who couldn’t attend or would like to revisit the material. You can access them here<\/a>.<\/p>\n\n\n\n February 8, 2024<\/p>\n The Carvunis lab is seeking undergraduate summer interns as part of the “adopt a proto-gene” initiative. This is a paid 10 week-long position from May 20th – July 26 2024, where undergraduates will learn how to design and execute a research experiment while gaining experience in techniques such as cloning, microbial phenotyping, high throughput robotics, and bioinformatics. Applications are due by March 5th. The link to the advertisement is here<\/a>.<\/a><\/p>\n January 18, 2023<\/p>\n A protocol paper on iRibo, a software program that can massively integrate ribosome profiling experiments to generate a species’s translatome, is now published in STAR Protocols here<\/a>. The protocol describes the steps needed to generate the yeast translatome in Aaron’s Cell Systems<\/em> paper.<\/p>\n January 2, 2023<\/p>\n A new preprint by our collaborator Nikolaos Vakirlis and former lab members Omer Acar and Vijay Cherupally formally evaluates the applicability of Ancestral Sequence Reconstruction (ASR) in the detection of de novo gene emergence. You can check it out here<\/a>.<\/p>\n December 4, 2023<\/p>\n Aaron’s preprint on the substantial limitations of shotgun mass-spectrometry in finding many biologically relevant lowly expressed proteins is now published in PLOS Biology. You can find the publication here<\/a>.<\/p>\n November 27, 2023<\/p>\n Saurin becomes the second PhD student from the Carvunis lab to successfully defend their PhD thesis this year. His work revolved around ‘Leveraging the genotype-phenotype relationship to explore the traditional and novel facets of cell biology.’ Saurin is going to join the Technology Transfer team at the University of Rochester in the new year. We wish him all the best for his future endeavors!<\/p>\n November 17, 2023<\/p>\n Multiple members of the Carvunis lab made it to the first ever conference on de novo gene birth with multiple posters and presentations to showcase the diversity of work that is done in the lab on this topic! We hope that this was the first of many such conferences. Please reach out to us if you were there and would love to learn more!<\/p>\n October 23, 2023<\/p>\n Summer students use computational prediction tools, co-expression analysis and fluorescence microscopy to suggest that an unannotated translated open reading frame in Saccharomyces cerevisiae<\/em> genome, which was systemically labeled YGR016C-A in Wacholder et al., 2023<\/a>, localizes to the endoplasmic reticulum. Read more about this tremendous effort here<\/a> and here<\/a>.<\/p>\n October 3, 2023<\/p>\n It was announced on October 3rd 2023 that the Carvunis Lab is going to receive the prestigious NIH Director’s Transformative Research Award (TRA)! A part of NIH’s High-<\/a>Risk<\/a>, High-Reward Research program<\/a>, the TRA supports “individuals or teams proposing transformative projects that are inherently risky and untested<\/strong> but have the potential to create or overturn fundamental paradigms<\/strong>” ! The Carvunis Lab is honored to have received this award along with the Joglekar<\/a>, Atianand<\/a> and Subramaniam<\/a> Labs.<\/p>\n August 25, 2023<\/p>\n April won the Best Student Talk at the CPCB retreat! Congratulations!<\/p>\n August 21, 2023<\/p>\n April\u2019s science YouTube channel bioZone was featured in the summer 2023 edition of Pitt Med magazine. Check out the Pitt Med article “These student YouTubers are in the zone ” here<\/a> and check out her YouTube channel here<\/a>.<\/p>\n August 18, 2023<\/p>\n The Lord and Carvunis Labs take best advantage of a sunny day in the Burgh to celebrate a joint lab picnic!<\/p>\n June 30, 2023<\/p>\n Jiwon won the 2023 Catalyst Award<\/a> from the Pittsburgh Center for Evolutionary Biology and Medicine (CEBaM). The Catalyst Program provides funding to PhD students and postdoctoral scholars at the University of Pittsburgh to perform research at the interface of evolutionary biology and medicine. Congratulations Jiwon!!!<\/p>\n June 22, 2023<\/p>\n This week is the last week for Omer, the first Ph.D. from the Carvunis lab. We got together to celebrate this big milestone for Omer (Dr. Acar!), Dr. Carvunis, and the lab. The lab prepared a little gift for him and wish him all the best for his new career in the industry.<\/p>\n May 18, 2023<\/p>\n Aaron identified the vast translatome of yeast through large-scale integration of ribosome-profiling data, and show that these translated elements are mostly evolutionarily transient. The work<\/a> is published in Cell Systems. Congratulations Aaron and coauthors!!<\/p>\n May 11, 2023<\/p>\n Omer defends his PhD thesis entitled “Understanding cellular innovation and complexity with a network perspective”. Congratulations Dr. Acar!!<\/p>\n May 3, 2023<\/p>\n The Carvunis Lab is excited to co-host a gene evolution workshop for instructors and educators, with a special focus on proto-genes! These unannotated, evolutionary novel genes offer unique insight into molecular evolution. No coding or software experience is required to participate. The workshop will be held via Zoom on June 13-14th, and registration is free! Registration ends June 5th. Register here<\/a> April 28, 2023<\/p>\n Check out this article in ASBMB Today Magazine<\/a>, showcasing the recent publication in Journal of Biological Chemistry from the Carvunis lab and collaborators on the function of the previously uncharacterized gene YLL058W.<\/p>\n April 24, 2023<\/p>\n Nelson received the 2023 Pitt Sustainability Award, which “recognize Pitt faculty, staff, students, and groups who are making an extraordinary impact on campus sustainability. These individuals or groups could have demonstrated their impact in one or more categories of the Pitt Sustainability Plan (Stewardship, Exploration, and\/or Community and Culture) via ideas, talents, and passions that contribute to a thriving culture of sustainability at Pitt.” Read more about the award here<\/a><\/p>\n April 10, 2023<\/p>\n The Carvunis Lab is honored to have been awarded the prestigious Human Frontier Science Program (HFSP) research grant! This grant promotes international collaboration and groundbreaking research. The funded project is entitled “New Kids on the Block: how DeNovo emerged micropeptides rewire cellular networks”. Read more about the HFSP grant here<\/a><\/p>\n March 31, 2023<\/p>\n Nelson has been selected as a Presidential Member for the Genetics Society of America. Congratulations Nelson! Read more here<\/a><\/p>\n March 20, 2023<\/p>\n New preprint from April and Omer looking at the transcription of noncanonical ORFs. Check out the preprint here<\/a><\/p>\n March 12, 2023<\/p>\n New preprint from Aaron about how the protein products of translated noncanonical ORFs in yeast can very rarely be detected using shotgun mass spectrometry data. Check out the preprint here<\/a><\/p>\n January 2, 2023<\/p>\n New perspective piece describing the work of An et al. which show that acquiring the ability to leave the nucleus is a major hurdle to cross towards becoming a protein-coding gene and the consequence of gaining such ability in one gene played a role in human brain evolution. Check out the perspective piece here<\/a>, check out An et al.’s paper here<\/a> and see Science’s news covering, featuring an interview from Dr. Carvunis here<\/a>.<\/p>\n December 16, 2022<\/p>\n Carvunis Lab’s NSF-funded Adopt a Proto-Gene initiative aims to get young researchers interested in proto-genes, improve evolutionary literacy and encourage STEM careers. Read more about it from two undergraduate students who experienced it this summer over here<\/a> in PITTMED’s winter 2022\/23 issue.<\/p>\n November 12, 2022<\/p>\n New collaborative research article by Branden, Saurin and Nelson et al. explores the mysterious growth of yeast cells lacking the MET15 gene in media lacking organosulfurs like methionine. They demonstrate through structural and evolutionary modeling, in vitro kinetic assays, and genetic complementation, that an alternative homocysteine synthase encoded by the previously uncharacterized gene YLL058W enables these cells to assimilate inorganic sulfur. Read more here<\/a> and here<\/a>.<\/p>\n August 26, 2022<\/p>\n April’s bioZone YouTube channel<\/a> received an award for their commitment to outreach from the CMU-Pitt Computational Biology Program<\/a>. Congratulations and well deserved April!!<\/p>\n August 12, 2022<\/p>\n New review article by the Carvunis lab members – Saurin, Carly, Branden and Aaron, on why the Yeasts are particularly well suited to address fundamental questions about de novo<\/em> gene emergence published in the Yeast journal. Read more about it and their new evolutionary systems biology approach for de novo<\/em> gene characterization over here<\/a> and here<\/a>.<\/p>\n July 13, 2022<\/p>\n A new paper about a community-led effort that produces a standardized catalog of 7,264 human Ribo-seq ORFs. Read more here<\/a>!<\/p>\n July 1, 2022<\/p>\n https:\/\/twitter.com\/carvunis\/status\/1542879318530981890?s=20&t=1FPBT8tlRsXksr8BEPpyLg<\/p>\n June 4, 2022<\/p>\n A new paper investigating the role of the RING finger protein RNF219 in post-transcriptional regulations. Read more here<\/a>!<\/p>\n June 2, 2022<\/p>\n A new paper from Omer Acar on identifying long-range interactions in genetic networks using elastic network models. Read more here<\/a>!<\/p>\n May 3, 2022<\/p>\n We had a wonderful retreat with our colleagues in the Pittsburgh Center for Evolutionary Biology and Medicine (CEBaM)<\/p>\n March 29, 2022<\/p>\n Funded by an NSF Career Award, the Carvunis lab is offering a paid 10 week-long summer position running from May 31st<\/sup>, 2022 to August 12th<\/sup>, 2022. The undergraduates will learn how to design and execute a research experiment while practicing various wet-lab techniques including cloning, microbial phenotyping, high throughput robotics, and bioinformatics. The undergraduates will meet weekly with their summer mentor, participate in the laboratory\u2019s journal clubs, attend small group meetings, local seminars, and present their research at the weekly group meeting at the end of the summer. Interested applicants should reach out to Kate McCourt with any question (kmm325 [at] pitt [dot] edu). The link to the advertisement is here.<\/a><\/p>\n March 25, 2022<\/p>\n Branden presented research from his new pre-print at the Pittsburgh Area Yeast Meeting followed by celebration afterwards on the team’s manuscript submission.<\/p>\n March 18, 2022<\/p>\n Carvunis lab enjoys another in-person lab meeting!<\/p>\n March 2, 2022<\/p>\n<\/div>\n Dr. Carvnuis has been awarded the 2022 Chancellor’s Distinguished Research Award for her innovative work on novel gene emergence. The award release describing Dr. Carvunis as ‘one of just a handful of the foremost experts on this phenomenon”.<\/p>\n Read more here<\/a> and here <\/a><\/p>\n Jan 20, 2022 \u201cThe Faculty Early Career Development (CAREER) Program is a Foundation-wide activity that offers the National Science Foundation\u2019s most prestigious awards in support of early-career faculty who have the potential to serve as academic role models in research and education and to lead advances in the mission of their department or organization.\u201d<\/p>\n Click here <\/a> for more information on the NSF CAREER award.<\/p>\n Jan 20, 2022<\/p>\n New preprint from Dr. Branden Van Oss et al. challenges current models of sulfur metabolism in yeast, with the discovery of another enzyme involved in homocysteine production. Read more here<\/a>.<\/p>\n Nov 23, 2021<\/p>\n Jiwon and Aaron have discovered SPAAR, a microprotein thought to be exclusively in placental mammals, actually exists in marsupials and monotremes like the platypus! Even though it is much more ancient than previously thought, it has changed a lot to the point of diverging almost beyond recognition, including a cool elongation in primates that appears under positive selection! Read more in out open access article<\/a> which is part of a Special Issue “How do new genes originate and evolve?<\/a>” with many more exciting articles on molecular innovation.<\/p>\n Oct 19, 2021<\/p>\n The Carvunis Lab celebrated the fall season with a field trip to a local pumpkin patch and apple orchard! We spent the day picking out pumpkins, picking apples, wandering through a corn maze, and sipping on warm apple cider. Happy autumn!<\/p>\n September 16, 2021 August 24, 2021 August 23, 2021 June 21, 2021 June 11, 2021 June 9, 2021 March 23, 2021 March 12, 2021 February 16, 2021 January 12, 2021 January 12, 2021 July 2, 2020 May 4, 2020 April 9, 2020 Feb 20, 2020 Feb 10, 2020<\/p>\n Check out this new publication<\/a> from the Carvunis Lab and collaborators in Nature Communications that investigates the De novo<\/em> emergence of adaptive membrane proteins!<\/p>\n Jan 23, 2020<\/p>\n Check out this preprint<\/a> accepted to Nature Communications on the de novo <\/em> emergence of adaptive membrane proteins, and this preprint<\/a> accepted to eLIFE that explores the origins of orphan genes. Stay tuned for the updated published versions!<\/p>\n Jan 23, 2020<\/p>\n How is the concept of function shaped by the diverse perspectives of scientists within and across disciplines? Anne-Ruxandra and colleagues explore the use of function in research of de novo <\/em>gene birth. Have a look at this article<\/a> in the rhetorics journal Poroi to learn more!<\/p>\n November 26, 2019<\/p>\n More good news!! Anne-Ruxandra gets recognized as the outstanding new PI of the month by an international community of early stage faculty. Find out more about her exciting profile by following this link: https:\/\/newpislack.wordpress.com\/2019\/11\/26\/anne-ruxandra-carvunis-ph-d\/<\/a><\/p>\n Read about other talented young PIs around the globe over here: https:\/\/newpislack.wordpress.com\/outstanding-new-pis\/<\/a><\/p>\n<\/div>\n November 15, 2019<\/p>\n A Science news article features the work of Anne-Ruxandra and her colleagues at the Ideker Lab<\/a> who have figured out a more scientific way of converting dog years to human years using DNA methylation signature. Find the news article here<\/a> and the preprint here<\/a>.<\/p>\n November 1, 2019<\/p>\n Anne-Ruxandra and colleagues explore the various meanings of ‘function’ in biology and its implications on the field of de novo <\/em>gene birth. Have a look at this thought provoking article<\/a> and let’s start a conversation on ‘function’.<\/p>\n November 1, 2019<\/p>\n Carvunis Lab celebrated Halloween in style this year! We not only had a costume-style lab meeting but also hosted this years Halloween party at work. It is important to remind everyone that doing science is not the only scary part of life!<\/p>\n October 30, 2019<\/p>\n Anne-Ruxandra made news for receiving the prestigious NIH Director’s New Innovator Award and Carly was the ‘Student Highlight’ in the latest edition of the Computational & Systems Biology Department’s newsletter. Find out more about Anne-Ruxandra’s award and Carly’s life in science, Pittsburgh and the CPBP Program over here<\/a>.<\/p>\n October 18, 2019<\/p>\n Ubiquitous tiny little proteins that can boost or block the impact of their bigger kin! Read all about this fascinating phenomenon and how some of these can indeed be proto-genes in this Science feature<\/a>.<\/p>\n![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2026\/01\/pic1.png)
<\/figure>\n\n\n\n Happy Halloween 2025!! & New Journey of the Carvunis Lab <\/h2>\n\n\n\n
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<\/figure>\n\n\n\nCarvunis Lab Attends Microproteins Conference<\/h2>\n\n\n\n
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<\/figure>\n\n\n\nNelson Makes a Galette des Rois for King’s Day<\/h2>\n\n\n\n
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\n\n\n\nNew commentary paper from the Carvunis lab<\/h2>\n\n\n\n
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\n\n\n\nNew preprint on annotating human nORFs<\/h2>\n\n\n\n
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\n\n\n\nNew preprint on the cell processing of de novo<\/em> emerging proteins<\/h2>\n\n\n\n
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\n\n\n\nCongratulations to April for her awards<\/h2>\n\n\n\n
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\n\n\n\nFarewell for Our Summer Students and John<\/h2>\n\n\n\n
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\n\n\n\nNew publication on the coexpression network of noncanonical ORFs<\/h2>\n\n\n\n
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\n\n\n\nCarvnis Lab Picnic 2024<\/h2>\n\n\n\n
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\n\n\n\nThank you for participating in the “Gene Expression Analysis Workshop”<\/h2>\n\n\n\n
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\n<\/div><\/div>\n\n\nAccepting applications for undergraduate summer interns (paid position)<\/h2>\n
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\nProtocol paper on iRibo published<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2024\/01\/star_graphical_abstract_final-300x300.jpeg\")
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\nNew preprint on the use of Ancestral Sequence Reconstruction in studying de novo genes<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2024\/01\/asr_fig1_cropped-274x300.jpg\")
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\nNew publication on the limitations of MS to detect the noncanonical translatome<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2023\/03\/figure2_aaron_ms-272x300.png\")
<\/p>\n
\nSaurin successfully defends his PhD thesis!<\/h2>\n
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<\/p>\n
\nCarvunis Lab at SMBE Satellite Meeting on De Novo Gene Birth<\/h2>\n
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\nSummer students publish a uPublication<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2023\/10\/summer2023_upublication-300x225.jpeg\")
<\/p>\n
\nCarvunis lab receives NIH Director’s Transformative Research Award!<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2023\/10\/HRHR-TRA-final-graphic3-240x300.jpg\")
<\/p>\n
\nApril won the Best Student Talk at the CPCB retreat<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2023\/08\/IMG_5834-300x225.jpg\")
<\/p>\n
\nApril’s BioZone was featured in the Pitt Med magazine<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2023\/08\/Screen-Shot-2023-08-21-at-4.43.09-PM-300x74.png\")
<\/p>\n
\nLord-Carvunis Lab Joint Lab Picnic<\/h2>\n
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<\/p>\n
\nJiwon won the CEBaM Catalyst Award<\/h2>\n
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\nFarewell party for Omer<\/h2>\n
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\nAaron’s yeast translatome paper is published in Cell Systems<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2023\/05\/Screen-Shot-2023-05-19-at-4.34.22-PM-287x300.png\")
<\/p>\n
\nOmer defends his PhD thesis!<\/h2>\n
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<\/p>\n
\nCarvunis lab is co-hosting online gene evolution workshop for educators<\/h2>\n
<\/h2>\n
<\/h2>\n
During this year’s online workshop, we will cover:<\/p>\n\n
For more information check out the adopt a proto-gene website<\/a> or email April at aar75[at]pitt[dot]edu<\/p>\n<\/h2>\n
![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2023\/05\/protogene_workshop_take4.png\")
<\/p>\n
\nResearch spotlight: “Life finds a way”<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2023\/04\/Yeast-petit-480x360-1.jpg\")
<\/p>\n
\nNelson receives Sustainability Award!<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2023\/04\/nelson_sustanability_large.png\")
<\/p>\n
\nCarvunis lab receives HFSP grant!<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2023\/04\/hfsp.png\")
<\/p>\n
\nNelson selected as a GSA Presidential Member<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2023\/03\/201014-Pres-Init-Signup-v1.jpg\")
<\/p>\n
\nNew preprint exploring the transcriptional network of noncanonical ORFs<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2023\/03\/Screen-Shot-2023-03-19-at-10.48.37-AM.png\")
<\/p>\n
\nNew preprint on the rarity of finding noncanonical ORFs in mass spectrometry<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2023\/03\/figure2_aaron_ms.png\")
<\/p>\n
\nNew perspective piece from the lab published in Nature Ecology & Evolution<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2023\/01\/Screenshot-from-2023-01-03-11-09-34.png\")
<\/p>\n
\nStudents can discover and \u201cadopt\u201d proto-genes<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2022\/12\/adapt_a_protogene.png\")
<\/p>\n
\nIn a collaborative paper the lab discovers a new enzyme!<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2022\/11\/yll_structural_prediction-300x197.png\")
<\/p>\n
\nApril\u2019s bioZone becomes an award winning YouTube channel<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2022\/08\/aprilbiozoneaward-300x208.jpeg\")
<\/p>\n
\nDe novo genes and Yeasts<\/h2>\n
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\nNew collaborative paper about translatome and annotation<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2022\/07\/Screen-Shot-2022-07-13-at-12.58.20-PM-1-300x119.png\")
<\/p>\n
\nAnne is promoted to Associate Professor with Tenure today! Congratulations!!!<\/h2>\n
\nNew collaborative paper about RNA processing<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2022\/06\/41598_2022_13309_Fig7_HTML.png-300x96.webp\")
<\/p>\n
<\/div>\nNew paper on information flow in genetic networks<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2021\/06\/network-300x144.jpg\")
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\n2022 CEBaM retreat<\/h2>\n
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\nUndergraduate Summer Research Position<\/b><\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2022\/03\/Panther_at_WPU-300x194.jpg\")
<\/p>\n
\nBranden presents at Pittsburgh Area Yeast Meeting<\/b><\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2022\/03\/Untitled-4-1.jpg\")
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\nIn-person lab meeting<\/b><\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2022\/03\/20220304_153715-1-scaled.jpg\")
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\nDr. Carvunis receives The Chancellor\u2019s Distinguished Research Award<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2022\/04\/20220401_AO_Faculty_Honors_0505-1024x508.png\")
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\nDr. Carvunis and lab receive NSF CAREER award<\/h2>\n
Dr. Carvunis and lab receive the National Science Foundation CAREER award to study how the widespread translation of evolutionary novel sequences impacts physiology and fitness in yeast. The research will be integrated with a far reaching educational project in collaboration with Primarily Undergraduate Institutions across the United States.<\/p>\n<\/h2>\n
![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2022\/01\/nsf.png\")
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\nNew preprint on sulfur metabolism in yeast<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2022\/01\/yll_met15_mety_struct-300x209.jpg\")
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<\/div>\nTracing the evolution of a mammalian microprotein<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2021\/11\/Screen-Shot-2021-11-24-at-12.06.17-PM-300x233.png\")
<\/p>\n
<\/div>\nHalloween’19<\/h2>\n
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<\/p>\n<\/div>\n
\nDr. Carvunis and Dr. Wacholder speak to Science Careers<\/h2>\n
Dr. Carvunis and Dr. Wacholder were interviewed for a recent article in Science Careers about the importance of performance reviews for early-career researchers and their advisors. Check out the article here<\/a>!<\/p>\n<\/h2>\n
![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2018\/01\/Anne_200-1.png\")
![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2018\/03\/Aaron.png\")
<\/p>\n<\/div>\n
\nHappy end of semester!<\/h2>\n
The Carvunis lab celebrates the end of the summer semester with some fun outdoors!<\/p>\n<\/h2>\n
![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2021\/08\/Image-from-iOS.jpg\")
<\/p>\n<\/div>\n <\/h2>\n
\nNew preprint investigating the evolutionarily transient translatome<\/h2>\n
New preprint from Aaron Wacholder that identified ~19,000 noncanonical translated elements through integration of multiple ribo-sequencing datasets. Read more here<\/a><\/p>\n<\/h2>\n
![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2021\/08\/wacholder2021.png\")
<\/p>\n<\/div>\n <\/h2>\n
\nCarvunis lab meets in person!<\/h2>\n
The Carvunis lab met for lab meeting in person for the first time in over a year! Great science presented by Jiwon followed by ice cream.<\/p>\n<\/h2>\n
![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2021\/06\/DSCF6388_smaller.jpg\")
<\/p>\n<\/div>\n <\/h2>\n
\nNew preprint on a collaboration towards a reference translatome using Ribo-seq<\/h2>\n
New preprint released discussing the challenges of ORF detection and annotation using ribo-sequencing. Read more here<\/a><\/p>\n<\/h2>\n
![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2021\/06\/riboseq_preprint_crop.png\")
<\/p>\n<\/div>\n <\/h2>\n
\nNew preprint on information flow in genetic networks<\/h2>\n
A new preprint from Omer Acar on identifying long-range interactions in genetic networks using elastic network models. Read more here<\/a>!<\/p>\n<\/h2>\n
![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2021\/06\/network.jpg\")
<\/p>\n<\/div>\n <\/h2>\n
\nApril Rich awarded Graduate Research Fellowship!<\/h2>\n
April Rich has been awarded the NSF Graduate Research Fellowship for her strong research potential and scientific communication outreach! Congratulations to April for this great accomplishment.<\/p>\n<\/h2>\n
![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2021\/03\/GRFP_logo-768x322.png\"){kind=logo}
<\/p>\n<\/div>\n
\nLI detector methodology published in G3!<\/h2>\n
The LI detector method for sensitive analysis of colony fitness in high throughput screens has been published in G3! Check it out here.<\/a><\/p>\n<\/h2>\n
![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2021\/01\/g3cover.png\")
![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2021\/01\/FIGURE1.png\")
<\/p>\n<\/div>\n
\nAnne-Ruxandra Carvunis wins 2021 Sloan Fellowship!<\/h2>\n
Anne-Ruxandra Carvunis has been selected as a 2021 Sloan Fellow.<\/a> This prestigious award is given to early-career scientists who “represent the most promising scientific researchers working today.” Congratulations to Dr. Carvunis for this remarkable achievement!<\/p>\n<\/h2>\n
![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2021\/02\/sloan_logo-300x76.png\"){kind=logo}
<\/p>\n<\/div>\n <\/h2>\n
\nApril Rich YouTube channel bioZone featured in Pittwire!<\/h2>\n
Check out this Pittwire article<\/a> featuring April Rich and her educational YouTube channel bioZone, which explores a variety of fascinating biological subjects. And check out her YouTube channel itself here.<\/a><\/p>\n<\/h2>\n
![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2021\/01\/screenshot2-300x169.jpg\")
<\/p>\n<\/div>\n
\nLI detector publication accepted in G3!<\/h2>\n
A new publication by Dr. Saurin Parikh and collaborators describing a novel method for analyzing mutant fitness in high throughput screens has been accepted for publication in G3. Congratulations Saurin!<\/p>\n<\/h2>\n
<\/p>\n<\/div>\n
\nNew publication in Cell Systems<\/h2>\n
Check out this new publication<\/a> from the Dr. Carvunis and collaborators in Cell Systems that investigates Dog-to-Human aging from a network biology perspective.<\/p>\n<\/h2>\n
![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2020\/07\/two-yellow-labrador-retriever-puppies-1108099.jpg\")
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<\/a><\/p>\n<\/div>\n
\nCarvunis Lab is a Green Lab now!<\/h2>\n
Carvunis Lab has been awarded with Green Lab Certificate showing our commitment to the good practices of recycling, re-use and reduce.<\/p>\n<\/h2>\n
![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2020\/05\/sust.png\")
<\/p>\n<\/div>\n
\nWhere do new genes come from?<\/h2>\n
Check out this new press article<\/a> in Quanta Magazine, spotlighting the recent publications in eLIFE<\/a> and Nature Communications<\/a> from the Carvunis lab and collaborators on the origins of new genes!<\/p>\n<\/h2>\n
![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2020\/04\/quanta.png\")
<\/a><\/p>\n<\/div>\n
\nNew publication in eLIFE<\/h2>\n
Check out this new publication<\/a> from the Dr. Carvunis and collaborators in eLIFE that explores the origins of orphan genes!
Also, here is a link to spotlight<\/a> in eLIFE.<\/p>\n<\/h2>\n
![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2020\/01\/F1-.jpg\")
<\/p>\n<\/div>\n
\nRecent Nature Communications Publication from Carvunis Lab and Collaborators<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2020\/02\/ybr.png\")
<\/a>![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2020\/02\/reconstructedtree.png\")
<\/a><\/p>\n<\/div>\n
\nTwo recent articles from the Carvunis Lab accepted to Nature Communications and eLIFE<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2020\/01\/F6.large_-1.png\")
<\/a><\/a><\/p>\n<\/div>\n
\nThe Recalcitrance and Resilience of Scientific Function<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2020\/01\/lepenseur-2.jpeg\")
<\/p>\n<\/div>\n
\nAnne-Ruxandra gets recognized as an outstanding new PI<\/h2>\n
\nHow old is your dog in human years?<\/h2>\n
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<\/a><\/p>\n<\/div>\n
\nThe meanings of ‘function’ in biology<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2019\/11\/Screen-Shot-2019-11-11-at-11.04.00-AM-300x181.png\")
<\/p>\n<\/div>\n
\nHalloween’19<\/h2>\n
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<\/p>\n<\/div>\n
\nCarvunis Lab members featured in the departmental newsletter<\/h2>\n
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![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2019\/11\/Screen-Shot-2019-11-11-at-9.35.10-AM-300x99.png\")
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<\/p>\n<\/div>\n
\nTiny proteins, huge impact<\/h2>\n
<\/h2>\n
![\"\"](\"https:\/\/carvunislab.csb.pitt.edu\/wp-content\/uploads\/2019\/10\/Screen-Shot-2019-10-18-at-7.17.31-AM-300x230.png\")
<\/p>\n<\/div>\n
\nNews feature on de novo<\/em> gene birth<\/h2>\n